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The CLcr in ml/min/1.73 Buy diarex silicone m 2 may be estimated from serum creatininemg/dldeterminationfor young adolescentschildren and infantsusing the following formulaSchwartz formula

No impact on fertility was detected in animal studiessee section 5.3No clinical data are availablepotential risk for human is unknown.

Potential drug interactions between KEPPRA and other AEDscarbamazepinegabapentinlamotriginephenobarbitalphenytoinprimidone and valproatewere also assessed by evaluating the serum concentrations of levetiracetam and these AEDs during placebo-controlled clinical studiesThese data indicate that levetiracetam does not influence the plasma concentration of other AEDs and that these AEDs do not influence the pharmacokinetics of levetiracetam.

The precise mechanism(sby which levetiracetam exerts its antiepileptic effect is unknownThe antiepileptic activity of levetiracetam was assessed in a number of animal models of epileptic seizuresLevetiracetam did not inhibit single seizures induced by maximal stimulation with electrical current or different chemoconvulsants and showed only minimal activity in submaximal stimulation and in threshold testsProtection was observedhoweveragainst secondarily generalized activity from focal seizures induced by pilocarpine and kainic acidtwo chemoconvulsants that induce seizures that mimic some features of human complex partial seizures with secondary generalizationLevetiracetam also displayed inhibitory properties in the kindling model in ratsanother model of human complex partial seizuresboth during kindling development and in the fully kindled stateThe predictive value of these animal models for specific types of human epilepsy is uncertain.

The following adverse reactions are discussed in more details in other sections of labeling:

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